bcaa

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  american journal of clinical nutrition, vol. 72, no. 2, 573s-578s, august 2000
  copyright 2000 american society for clinical nutrition
  serotonin and central nervous system fatigue: nutritional considerations
  j mark davis, nathan l alderson, and ralph s welsh
  
  for bcaas to be physiologically effective in reducing central fatigue, large doses are probably required. `large doses, however, are likely to increase the ammonia concentration in plasma, which is known to be toxic to the brain and muscle (36).` ıt has been suggested that buffering of ammonia could lead to early fatigue in working muscles by depleting glycolytically derived carbon skeletons (pyruvate) and draining intermediates of the tricarboxylic acid cycle (38). large doses of bcaa during exercise are also likely to slow water absorption across the gut, cause gastrointestinal disturbances, and decrease fluid palatability.
  
  http://www.ncbi.nlm.nih.gov/pubmed/19763733
  http://jp.physoc.org/content/486/pt_3/789.full.pdf
  
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